| 摘要 |
The present invention relates to new antimicrobial compounds, their synthesis and their use for treatment of mammalian infections. The present invention aims at the generation of new compounds with activity against mycobacteria as potential new tuberculosis drugs to overcome problems concerning resistance and drug intolerance. This aim has been solved by providing compounds of the formula 1 wherein Rand Rare, independently of each other, NO, NRR, NHOR, COOR, CN, CONRR, CHO, F, Cl, Br, SONR R, lower alkoxy, OCF, mono-, di or trifluoromethyl; Rand Rare, independently of each other, H, a saturated or unsaturated, linear or branched aliphatic radical having 1-3 chain members, F, Cl, Br, lower alkoxy; Ris H, a saturated or unsaturated, halogenated or unhalogenated, linear or branched aliphatic radical having 1-7 chain members; Ris a radical: wherein X is saturated or unsaturated, halogenated or unhalogenated, linear or branched aliphatic radical having 1-5 chain members, or Rand Rtogether represent bivalent radicals wherein n is 1-4; R- Rare, independently of each other H or a saturated or unsaturated, halogenated or unhalogenated, linear or branched aliphatic radical having 1-5 chain members, phenyl, benzyl or R and R together, Rand Rtogether, Rand Rtogether represent a linear or branched aliphatic bivalent radical having 1-7 chain members; Rand Rare, independently of each other, H, linear or branched aliphatic radical having 1-5 chain members, F, Cl, Br, NO, NHCF. |
