发明名称 |
ANTI-SENSE NUCLEIC ACID OF INHIBITING EXPRESSION OF GRANULIN-EPITHELIN-PRECURSOR GENE AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF |
摘要 |
PURPOSE: An antisense nucleic acid to granulin-epithelin precursor(GEP) and a composition containing the same are provided to suppress and treat hepatocellular carcinoma. CONSTITUTION: An antisense nucleic acid which suppresses granulin-epithelin precursor(GEP) expression contains siRNA having a base selected from sequence numbers 1-3; or shRNA having oligonucleotide(complementary oligonucleotide) which is linked to the siRNA through a linker sequence from the 5'-end or 3'-end. The shRNA has a base selected sequence numbers 4-9. A pharmaceutical composition for treating granulin-epithelin precursor-derived diseases contains the antisense nucleic acid or recombinant vector containing the nucleic acid.
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申请公布号 |
KR20120089387(A) |
申请公布日期 |
2012.08.10 |
申请号 |
KR20100110908 |
申请日期 |
2010.11.09 |
申请人 |
CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION |
发明人 |
NAM, JAE HWAN;PARK, MI YOUNG |
分类号 |
C12N15/113;A61K31/7105;A61K48/00;C12N15/86 |
主分类号 |
C12N15/113 |
代理机构 |
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地址 |
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