SOLID-SUPPORTED PRECURSOR COMPOUNDS FOR SYNTHESIS OF 18F RADIOPHARMACEUTICLAS, PREPARATION METHOD AND APPLICATIONS THEROF

摘要

PURPOSE: A precursor compound connected to a solid supporter for manufacturing 18f radiopharmaceutical products marked as f-18 and manufacturing method and application thereof are provided to omit excessive amount of phase transfer catalyst use and fluoride refining process. CONSTITUTION: A precursor compound is represented by chemical formula 1. Here, the solid supporter is an insoluble organic polymer or an insoluble inorganic oxide. A indicates a linker, B indicates an organic cation, and C indicates a single bond, -O- or -D-SO2-O-. Here, D indicates the single bond or C1-30 hydrocarbon group. In the hydrocarbon radical, one or more selected from a group consisting of nitrogen, oxygen and sulfur can be placed and the hydrocarbon radical is substituted or non-substituted with halogen. R indicates an organic group which excepts F-18 among radiopharmaceutical products marked as 18F. Hydrogen inside the organic group is non-substituted or substituted with a blocking group. X indicates a negative ion.