COMPLEX OF TRIS-(2-HYDROXYETHYL)AMINE WITH ZINK BIS-(2-METHYLPHENOXYACETATE), INCREASING CYTOKIN ACTIVITY OF TOTAL TRIPTOPHANYL-tRNA-SYNTHETASE

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed is application of complex of tris-(2-hydroxyethyl)amine with zink bis-(2-methylphenoxyacetate) [cresoxyzinkatrane] of formula (HOCH2CH2)3NZn(OOCCH2OC6H4CH3-2)2 as stimulator of cytokine activity of total triptophanyl-tRNK synthetase. Demonstrated is increase of total triptophanyl-tRNK synthetase by 50% in comparison with control in dose 5 mg/kg with intramuscular introduction during 2 months; introduction of cresoxyzinkatrane in the same dose but together (simultaneously) with cholesterol during 3 months also produces expressed effect - increase of TRSase level. ^ EFFECT: invention can be used in medicine and biology as basis for creation of medications of anti-sclerosis action, for instance, for prevention of sclerotic affection of blood vessels. ^ 1 dwg