发明名称 |
DUAL VECTOR FOR INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS |
摘要 |
The present invention provides an expression vector for preventing or inhibiting HIV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HIV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.
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申请公布号 |
US2012201794(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
US201013384206 |
申请日期 |
2010.05.26 |
申请人 |
CHEN IRVIN;AN DONG SUNG;MILLINGTON MICHELLE L.;BOYD MAUREEN P.;SYMONDS GEOFFREY P.;BRETON LOUIS RANDALL;CALIMMUNE INC. |
发明人 |
CHEN IRVIN;AN DONG SUNG;MILLINGTON MICHELLE L.;BOYD MAUREEN P.;SYMONDS GEOFFREY P.;BRETON LOUIS RANDALL |
分类号 |
A61K31/713;A61K35/14;A61P31/18;C12N5/10;C12N15/85;C12N15/86;C12N15/867 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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