摘要 |
The invention relates to the pharmaceutical industry and to medicine, specifically to novel hydrated amino-acid derivatives of fullerene ?60 of general formula C60(H)3{NH(CH2)nCOOH}3·xH2O, where ?60 - fullerene, n = 5, 6, 7, ? = 8 - 10, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions on the basis thereof. Hydrated N-fullerene amino acids are formed in the interaction of fullerene with 15 times the molar excess of anhydrous potassium salts of amino acids in a medium of organic aromatic solvent with slow addition to the resultant suspension of an interphase catalyst and with mixing and heating to a temperature not exceeding 60 °? until the solution is completely decolorized and a solid residue formed, after which the latter is separated out, and then 0.8 M of aqueous solutions of potassium salts of fullerene amino-acid derivatives is treated with a solution of organic or mineral acids, followed by centrifugation, rinsing and drying of the residue. A pharmaceutical composition which exhibits activity against the herpes virus, flu viruses of various origin and HIV, and also anti-tumour and anti-psoriatic activity, comprising, as active substance, an effective quantity of hydrated N-fullerene amino acids. |
申请人 |
RASNETSOV, LEV DAVIDOVICH;SHVARTSMAN, LAKOV YUDELEVICH;SUVOROVA, OLGA NIKOLAEVNA |
发明人 |
RASNETSOV, LEV DAVIDOVICH;SHVARTSMAN, LAKOV YUDELEVICH;SUVOROVA, OLGA NIKOLAEVNA |