发明名称 |
SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) |
摘要 |
The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders. |
申请公布号 |
US2012202795(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
US201213449711 |
申请日期 |
2012.04.18 |
申请人 |
WEINTRAUB PHILIP M.;EASTWOOD PAUL R.;MEHDI SHUJAATH;STEFANY DAVID W.;MUSICK KWON YON;MOORCROFT NEIL;LIM SUNGTAEK;JIANG JOHN Z.;RUTTEN HARTMUT;PEUKERT STEFAN;SCHWAHN UWE;AVENTIS PHARMACEUTICALS INC. |
发明人 |
WEINTRAUB PHILIP M.;EASTWOOD PAUL R.;MEHDI SHUJAATH;STEFANY DAVID W.;MUSICK KWON YON;MOORCROFT NEIL;LIM SUNGTAEK;JIANG JOHN Z.;RUTTEN HARTMUT;PEUKERT STEFAN;SCHWAHN UWE |
分类号 |
A61K31/4412;A61K31/44;A61K31/444;A61K31/4545;A61K31/472;A61K31/496;A61K31/497;A61K31/506;A61K31/5377;A61K31/551;A61P9/00;A61P9/10;A61P25/00;A61P25/28;C07D213/62;C07D213/64;C07D217/24;C07D401/04;C07D401/10;C07D401/14;C07D405/04;C07D405/14;C07D409/04;C07D409/14;C07D413/04;C07D413/10;C07D413/14;C07D417/14;C07D491/113 |
主分类号 |
A61K31/4412 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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