摘要 |
The invention comprises a mixture of esters of 3 : 5 : 5-trimethylcyclohexanol and dl-mandelic acid which consists substantially of esters derived from the low-melting isomer of the alcohol and is completely or substantially free from esters derived from the higher-melting isomer of the alcohol, and the preparation thereof by esterification of 3 : 5 : 5-trimethylcyclohexanol with dl mandelic acid and distilling the crude ester mixture. An example describes the preparation, the distillation being carried out at a pressure of 10 mm. of mercury, while excluding oxygen, the fraction boiling at 184-8 DEG C. being collected.ALSO:The invention includes a pharmaceutical preparation comprising in admixture a mixture of esters of 3 : 5 : 5-trimethyl-cyclohexanol and dl-mandelic acid, which consists substantially of esters derived from the low-melting isomer of the alcohol and is completely or substantially free from esters derived from the high-melting isomer of the alcohol, with a therapeutically suitable vehicle. |