发明名称 |
METHODS OF ALTERING BONE GROWTH BY ADMINISTRATION OF SOST OR WISE ANTAGONIST OR AGONIST |
摘要 |
The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating of a Sost antagonist are also disclosed, as it a method of increasing bone density by administering to a mammalian patient a therapeutic amount of a Sost antagonist together with an antiresorptive drug.
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申请公布号 |
US2012201815(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
US201213420846 |
申请日期 |
2012.03.15 |
申请人 |
ELLIES DEBRA L.;OSTEOGENEX INC. |
发明人 |
ELLIES DEBRA L. |
分类号 |
A61K39/395;A61P13/12;A61P19/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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