发明名称 |
Compositions and Methods for Inhibiting an Oncogenic Protein to Enhance Immunogenicity |
摘要 |
The present invention includes compositions and methods for inhibiting an oncogenic protein or its down-stream effector protein to suppress expression of a cell-surface protein involved in inhibiting immune response against malignant cells thereby enhancing immunogenicity of a cell. The invention includes inhibitors of expression of CD274 and/or its functional cell-membrane bound immunosuppressive analog. The invention includes inhibitors of function or expression of oncogenic ALK tyrosine kinase and/or other oncogenic proteins responsible for induction of expression of CD274 or its functional immunosuppressive equivalent. The invention includes inhibitors of function or expression of STAT3 and/or other cell signal transmitters and/or transcription factors activated by ALK or its functional analog involved in induction of expression of CD274 or its functional analog.
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申请公布号 |
US2012201824(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
US201113128828 |
申请日期 |
2011.12.08 |
申请人 |
WASIK MARIUSZ |
发明人 |
WASIK MARIUSZ |
分类号 |
A61K39/395;A61K31/713;A61K38/02;A61K39/00;A61P35/00;A61P37/04;C07H21/02;C07K2/00;C07K16/18;C12N5/09;C12N15/85;C12Q1/02;C12Q1/68;C40B30/04;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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