OLIGONUCLEIC ACID COMPOSITION AND ANTIALLERGIC AGENT

摘要

An oligonucleic acid composition which contains: an oligonucleic acid having antiallergic activity and antimicrobial activity (such as an siRNA that suppresses transcription factor NF-?B); a cell-penetrating peptide (a basic peptide which comprises arginine, histidine, and cysteine at both ends and which is modified with a higher fatty acid); and if necessary, a tight junction opening peptide. The cell-penetrating peptide may electrostatically form a composite with the oligonucleic acid, or may form a crosslinked composite by a disulfide bond. Since the oligonucleic acid composition has high stability of the oligonucleic acid, high cutaneous permeability and high mucosal permeability and is thus capable of delivering an oligonucleic acid to a target cell, allergic diseases and infectious diseases can be effectively treated by administration of the oligonucleic acid composition through skin or mucosa.