The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
申请公布号
WO2012106525(A2)
申请公布日期
2012.08.09
申请号
WO2012US23646
申请日期
2012.02.02
申请人
EXACT SCIENCES CORPORATION;MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;AHLQUIST, DAVID A.;TAYLOR, WILLIAM R.;ZOU, HONGZHI;LIDGARD, GRAHAM P.
发明人
AHLQUIST, DAVID A.;TAYLOR, WILLIAM R.;ZOU, HONGZHI;LIDGARD, GRAHAM P.