DERMAL COMPOSITION COMPRISING POLYMERIC REVERSED MICELLE, AND METHOD FOR PRODUCING SAME

摘要

The present invention addresses the problem of providing a dermal composition comprising a polymeric reversed micelle that allows a water-soluble drug to be efficiently encapsulated and that is very safe and superior in transdermal absorbability, and providing a method that can produce the composition in simple steps. The dermal composition comprises a polymeric reversed micelle composed of an amphipathic polymer having a hydrophilic segment and a hydrophobic segment, wherein the polymeric reversed micelle has a configuration in which the hydrophilic segment is the core and the hydrophobic segment is the shell, and a water-soluble drug is enclosed therein. The composition can be produced by mixing an oil phase containing the amphipathic polymer in an oily base agent and an aqueous phase containing the water-soluble drug in an aqueous solvent, or by mixing an oily base agent and an aqueous phase containing the amphipathic polymer and the water-soluble drug in an aqueous solvent.