FXR INHIBITOR, BILE ACID SEQUESTRANT AS COMBINATION THERAPY FOR CHOLESTEROL REDUCTION

摘要

This invention relates to a composition containing both a bile acid sequestrant and a Farnesoid X Receptor antagonist and a method of administering the composition to a subject to modulate lipid metabolism, specifically, to increase cholesterol transport, to decrease Low-Density Lipoprotein Cholesterol (LDL-C), and/or to reduce the risk of atherosclerosis therein. This composition can be used to treat a patient having a cardiovascular disease, atherosclerosis, and/or gallstones.