发明名称 |
USE OF AN ANTI-CD200 ANTIBODY FOR PROLONGING THE SURVIVAL OF ALLOGRAFTS |
摘要 |
The present disclosure provides methods useful for prolonging the survival of an allograft organ in a recipient mammal. The methods include administration of an anti-CD200 antibody or a CD200-binding fragment of the antibody. The disclosure also provides biomarkers, a change in one or more of which indicates that an anti- CD200 antibody has produced a desired immunomodulatory effect in a mammal. Also featured are pharmaceutical compositions, kits, and solutions that contain at least one anti-CD200 antibody and are useful in the methods described herein. |
申请公布号 |
CA2826453(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
CA20122826453 |
申请日期 |
2012.02.03 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
WANG, YI;FAAS MCKNIGHT, SUSAN;YU, ZHAO XUE;WANG, HAO |
分类号 |
A61K39/395;A61P37/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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