发明名称 |
MUTANT LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN WITH INCREASED BINDING TO ALZHEIMER AMYLOID-BETA PEPTIDE |
摘要 |
A mutant low-density lipoprotein receptor related protein-1 binds to Alzheimer amyloid-beta (Aβ) peptide with greater affinity compared to its wild-type homolog. This binding may be used to detect Aβor to separate Aβfrom the rest of a subject's body. In Alzheimer disease, it may be used to provide diagnostic results by detecting Aβ, treatment by removing Aβ, or both.
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申请公布号 |
US2012201757(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
US201013501877 |
申请日期 |
2010.10.18 |
申请人 |
ZLOKOVIC BERISLAV V.;SRIVASTAVA ALAKA;DEANE RASHID |
发明人 |
ZLOKOVIC BERISLAV V.;SRIVASTAVA ALAKA;DEANE RASHID |
分类号 |
A61K49/00;A61K38/17;A61P25/28;C07K14/705;C07K19/00;G01N33/566 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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