TESTOSTERONAN, A NOVEL HEPAROSAN ANALOG, TESTOSTERONAN SYNTHASE, AND METHODS OF PRODUCTION AND USE THEREOF

摘要

Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-a1,4-D-GlcNAc-a1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes UDP-GlcUA and UDP-GlcNAc to synthesize a polysaccharide having the structure [-4-D-GlcUA- a1,4-D-GlcNAc-a1-]n.