发明名称 |
COMPOSITION FOR CONTROL OF SKIN CELL DIFFERENTIATION COMPRISING DUOX 2 MIRNA |
摘要 |
<p>PURPOSE: A composition containing miRNA molecule or mimic of DUOX2 for controlling skin cell differentiation is provided to regulate DUOX2, filagrin, loricrin, keratin 1, and keratin 10 genes. CONSTITUTION: A composition for controlling skin cell differentiation contains miRNA molecule or mimic of DUOX2 having 7-25 bases with a base sequence of sequence number 1. The miRNA molecule or mimic targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition promotes skin cell differentiation. A miRNA inhibitor of DUOX2 targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition suppresses skin cell differentiation. The skin cell is keratinocytes.</p> |
申请公布号 |
KR20120088896(A) |
申请公布日期 |
2012.08.09 |
申请号 |
KR20100115854 |
申请日期 |
2010.11.19 |
申请人 |
AMOREPACIFIC CORPORATION |
发明人 |
CHOI, HYUN;KIM, YEUN KYUNG;KIM, KYU HAN;LEE, TAE RYONG;NOH, MIN SOO;SHIN, DONG WOOK |
分类号 |
C12N15/113;A61K31/7105;C12N5/071;C12Q1/68 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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