发明名称 |
Vaccine composition containing synthetic adjuvant |
摘要 |
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier. |
申请公布号 |
EP2484375(A2) |
申请公布日期 |
2012.08.08 |
申请号 |
EP20120153249 |
申请日期 |
2007.09.26 |
申请人 |
INFECTIOUS DISEASE RESEARCH INSTITUTE |
发明人 |
REED, STEVEN, G.;CARTER, DARRICK |
分类号 |
A61K39/00;A61K39/35;A61K39/39;A61K45/06 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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