Useful Combinations of Monobactam Antibiotics with beta-Lac-tamase Inhibitors

摘要

A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula I:
with a ²-lactamase inhibitor of one of the formulae II to XIII are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another ²-lactamase inhibitor of one of the formulae II to XIII, particularly of formula V or formula VI.