发明名称 |
CROSSLINKED HYDROGELS AND RELATED METHOD OF PREPARATION |
摘要 |
The present invention provides a method of manufacturing a hydrogel comprising the step of crosslinking a biopolymer using a carbodiimide crosslinker of Formula I wherein at least one of R1 and R2 is a functional group that is a bulky organic functional group. R1 and R2 can each independently be an optionally substituted saturated or unsaturated functional group selected from the group consisting of an alkyl, a cycloalkyl, a heterocyclic, and an aryl. The bulky organic functional group will slow down the crosslinking reaction of carbodiimide due to the steric effects and/or electronic effects, in comparison to a crosslinking reaction using EDC. Also provided are the hydrogels and ophthalmic devices prepared using the method of the invention and uses thereof. |
申请公布号 |
EP2483332(A1) |
申请公布日期 |
2012.08.08 |
申请号 |
EP20100819764 |
申请日期 |
2010.09.29 |
申请人 |
OTTAWA HOSPITAL RESEARCH INSTITUTE;UNIVERSITY OF OTTAWA |
发明人 |
GRIFFITH , MAY;LI , FENGFU;AHN , JAE-IL |
分类号 |
C08J3/24;A61K9/107;A61K31/522;A61L27/14;A61L31/06;A61P27/02;A61P31/22;C08J3/075;C08K5/42;C08L89/06 |
主分类号 |
C08J3/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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