| 摘要 |
A method of making medicinal capsules comprising medicines in predetermined doses dispersed in a carrier comprises preparing a solution or dispersion of the medicine in an aqueous solution of a swellable colloid, e.g., gelatin, agar-agar, gum acacia, pectin, starch, tragacanth or casein, warming the solution, e.g., to 50 DEG C. and adding dropwise to a water immiscible liquid of lower density than the solution or dispersion and which is contained in a tall cylinder, the top part of which is maintained at a temperature akin to the solution and the bottom of which is maintained at a temperature at which the colloidal carrier is solid. The droplets, as they descend the cylinder congeal to form solid "pearls" containing an amount of medicine determined by the size of each droplet. Specification 708,160 [Group VI] is referred to.ALSO:A method of preparing medicines in doses dispersed in a carrier, comprises preparing a solution or dispersion of the medicine in an aqueous solution of a swellable colloid, e.g. gelatin, agar-agar, gum acacia, pectin, starch, tragacanth or casein. This solution or dispersion is then added dropwise, after warming, e.g. to 50 DEG C., to a water-immiscible liquid of lower density than the solution or dispersion and which is also a non-solvent for the medicine, e.g. paraffin oil, or an animal or vegetable oil. This liquid is contained in a tall vertical vessel, the top part of which is maintained at a temperature similar to the colloidal dispersion or solution, e.g. 50 DEG C., and the bottom of which is at a lower temperature, e.g. 20 DEG C. On descending the vessel the drops congeal forming "pearls," containing the medicine dispersed in the carrier. The "pearls" are incompletely washed with benzene to remove part of the adhering oil, dried and washed free of all oil. Water may be removed with a water-miscible solvent, e.g. acetone, methanol, ethanol, propanol or dioxan. The colloidal solution may also contain a plasticizing agent, e.g. glucose, sorbitol, glycol or hevey. If the medicine has been incorporated in an oil form and clear "pearls" are required, resin may be added to the oil phase of the dispersion to equalize the refractive indices of the two phases. The pH of the colloidal solution or dispersion is adjusted closely to the isoelectric point of the swellable colloid used, before pouring dropwise into the congealing medium. If a cellulose derivative, e.g. carboxymethyl cellulose, is used as the carrier, the coagulating vessel may contain an aqueous solution of an acid, or an organic solvent. The example given is for a multivitamin preparation. Specification 708,160 is referred to. |
