发明名称 |
BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER |
摘要 |
The invention relates to benzoxazepin compounds of Formula I
including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring which compounds have anti-cancer activity, and more specifically, inhibit PI3 kinase activity. |
申请公布号 |
EP2483278(A1) |
申请公布日期 |
2012.08.08 |
申请号 |
EP20100757213 |
申请日期 |
2010.09.27 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
BLAQUIERE, NICOLE;DO, STEVEN;DUDLEY, DANETTE;FOLKES, ADRIAN J.;HEALD, ROBERT;HEFFRON, TIMOTHY;JONES, MARK;KOLESNIKOV, ALEKSANDR;NDUBAKU, CHUDI;OLIVERO, ALAN G.;PRICE, STEPHEN;STABEN, STEVEN;WANG, LAN |
分类号 |
C07D498/04;A61K31/4162;A61K31/4188;A61K31/4196;A61P35/00;C07D498/14;C07D519/00 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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