CYCLOALKYL-SUBSTITUTED IMIDAZOLE DERIVATIVE.

摘要

Compounds represented by general formula (I) (wherein A represents a C_3-12 cycloalkyl group optionally substituted by 1-3 substituents selected from among fluoro groups, hydroxide groups and/or a C_1-6 alkyl groups; R1, R2 and R3 each individually represents a hydrogen atom, a fluoro group or a C_1-6 alkyl group; R4 represents a hydrogen atom or a prodrug group;and Y represents -CH₂-CHR5-CH₂-NHR6, in which R5 represents a hydrogen atom, a C_1-6 alkyl group or a C_1-6 alkoxy group and R6 represents a hydrogen atom or a prodrug group) and pharmacologically-acceptable salts thereof exhibit a TAFIa-inhibiting activity, and thus are useful as therapeutic drugs for myocardial infarction, angina, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, etc.