发明名称 |
SYNTHETIC OPLOPHORUS RUCIFERASES WITH ENHANCED LIGHT OUTPUT |
摘要 |
The present invention discloses a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type Oplophorus luciferase and includes at least one amino acid substitution at a position corresponding to an amino acid in a wild-type Oplophorus luciferase of SEQ ID NO: 1. The modified luciferase polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the wild-type Oplophorus luciferase. |
申请公布号 |
KR20120088548(A) |
申请公布日期 |
2012.08.08 |
申请号 |
KR20117028749 |
申请日期 |
2010.05.03 |
申请人 |
PROMEGA CORPORATION |
发明人 |
ENCELL LANCE P.;WOOD KEITH V.;WOOD MONIKA G.;HALL MARY;OTTO PAUL;VIDUGIRIS GEDIMINAS;ZIMMERMAN KRISTOPHER |
分类号 |
C12N15/52;C07K19/00;C12N15/85;C12Q1/66 |
主分类号 |
C12N15/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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