发明名称 |
Multimodal, multifunctional polymer coated nanoparticles |
摘要 |
Disclosed are nanoparticles having a metallic core consisting essentially of superparamagnetic iron oxide; a polymeric coat surrounding said core, the coat having a matrix of polyacrylic acid and forming an outer periphery of said nanoparticle; a plurality of hydrophobic pockets formed by the polymeric coat; a plurality of carboxylic groups along an outer periphery of the polymeric coat and effective to conjugate with a predetermined targeting ligand which functionalizes the nanoparticle; a lipophylic fluorescent dye encapsulated in the plurality of hydrophobic pockets; and a drug encapsulated in the plurality of hydrophobic pockets. Associated methods of making the nanoparticles and of treatments using the nanoparticles are also disclosed.
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申请公布号 |
US8236284(B1) |
申请公布日期 |
2012.08.07 |
申请号 |
US20090416993 |
申请日期 |
2009.04.02 |
申请人 |
PEREZ J. MANUEL;SANTRA SANTIMUKUL;UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
PEREZ J. MANUEL;SANTRA SANTIMUKUL |
分类号 |
A61K9/14;A01N59/16 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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