发明名称 |
Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms |
摘要 |
Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates. |
申请公布号 |
US8236960(B2) |
申请公布日期 |
2012.08.07 |
申请号 |
US201113081427 |
申请日期 |
2011.04.06 |
申请人 |
THYGESEN MIKKEL BOAS;SCHLIENGER NATHALIE;TOLF BO-RAGNAR;ANDERSSON CARL-MAGNUS A.;BLATTER FRITZ;BERGHAUSEN JOERG;ACADIA PHARMACEUTICALS INC. |
发明人 |
THYGESEN MIKKEL BOAS;SCHLIENGER NATHALIE;TOLF BO-RAGNAR;ANDERSSON CARL-MAGNUS A.;BLATTER FRITZ;BERGHAUSEN JOERG |
分类号 |
C07D211/56;A61K31/445 |
主分类号 |
C07D211/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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