发明名称 |
Compositions and methods for siRNA inhibition of HIF-1 α |
摘要 |
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer. |
申请公布号 |
US8236775(B2) |
申请公布日期 |
2012.08.07 |
申请号 |
US20090630077 |
申请日期 |
2009.12.03 |
申请人 |
REICH SAMUEL JOTHAM;SURACE ENRICO MARIA;TOLENTINO MICHAEL J.;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
REICH SAMUEL JOTHAM;SURACE ENRICO MARIA;TOLENTINO MICHAEL J. |
分类号 |
A61K31/70;A61K38/00;C07H21/02;C07H21/04;C12N15/113;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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