发明名称 |
Uses of synthetic peptide amides |
摘要 |
The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: wherein Xaa is a D-amino acid and G is selected from the following three groups: The compounds are useful in the prophylaxis and treatment of pain, pruritus and inflammation associated with a variety of diseases and conditions. |
申请公布号 |
US8236766(B2) |
申请公布日期 |
2012.08.07 |
申请号 |
US20090480059 |
申请日期 |
2009.06.08 |
申请人 |
SCHTEINGART CLAUDIO D.;MENZAGHI FREDERIQUE;JIANG GUANGCHENG;ALEXANDER ROBERTA VEZZA;SUEIRAS-DIAZ JAVIER;SPENCER ROBERT H.;CHALMERS DEREK T.;LUO ZHIYONG;CARA THERAPEUTICS, INC. |
发明人 |
SCHTEINGART CLAUDIO D.;MENZAGHI FREDERIQUE;JIANG GUANGCHENG;ALEXANDER ROBERTA VEZZA;SUEIRAS-DIAZ JAVIER;SPENCER ROBERT H.;CHALMERS DEREK T.;LUO ZHIYONG |
分类号 |
A61K38/07 |
主分类号 |
A61K38/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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