Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication

摘要

The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I), a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C1-10alkanediyl; R is Ar<1> or a monocyclic or bicyclic heterocycle Q is R<7>, pyrrolidinyl substituted with R<7>, piperidinyl substituted with R<7> or homopiperidinyl substituted with R<7>; one of R<2a >and R<3a >is selected from halo, optionally mono- or polysubstituted Cl-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar<2>, N(R<4a>R<4>), N(R<4a>R<4>)sulfonyl, N(R<4a>R<4b>)carbonyl, C1-6alkyloxy, Ar<2>oxy, Ar<2>Cl-6alkyloxy, carboxyl, Cl-6alkyloxycarbonyl, or -C(=Z)Ar<2>; and the other one of R<2a >and R<3a> is hydrogen; in case R<2a >is different from hydrogen then R<2b >is hydrogen, C1-6alkyl or halogen and R<3b >is hydrogen; in case R<3a >is different from hydrogen then R<3b> is hydrogen, C1-6alkyl or halogen and R<2b >is hydrogen. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine.