Process for preparation of (R)-(-)-2-hydroxy-2-(2- chlorophenyl)acetic acid and its salt

摘要

It is described a process for the preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the general formula (I), wherein the racemic 2-hydroxy-2-(2- chlorophenyl)acetic acid is resolved with a substituted amine of the general formula (II), where R21means hydroxymethyl group or carboxyl group, R2 means phenyl group, nitrophenyl group or a C1-C4 alkyl group substituted with an amino group, R3 means hydroxyl group or hydrogen atom.