发明名称 |
DNA SEQUENCING USING MULTIPLE METAL LAYER STRUCTURE WITH ORGANIC COATINGS FORMING TRANSIENT BONDING TO DNA BASES |
摘要 |
A nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base. |
申请公布号 |
US2012193231(A1) |
申请公布日期 |
2012.08.02 |
申请号 |
US201213359750 |
申请日期 |
2012.01.27 |
申请人 |
AFZALI-ARDAKANI ALI;HARRER STEFAN;LUAN BINQUAN;MARTYNA GLENN J.;PENG HONGBO;ROSSNAGEL STEPHEN M.;STOLOVITZKY GUSTAVO A.;WAGGONER PHILIP S.;WALKER GEORGE F.;INTERNATIONAL BUSINESS MACHINES CORPORATION |
发明人 |
AFZALI-ARDAKANI ALI;HARRER STEFAN;LUAN BINQUAN;MARTYNA GLENN J.;PENG HONGBO;ROSSNAGEL STEPHEN M.;STOLOVITZKY GUSTAVO A.;WAGGONER PHILIP S.;WALKER GEORGE F. |
分类号 |
G01N27/447;G01N27/453 |
主分类号 |
G01N27/447 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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