<p>The present invention provides preparations of MSCs with important therapeutic potential. The MSC cells are non-primary cells with an antigen profile comprising less than about 1.25% CD45+ cells (or less than about 0.75% CD45+), at least about 95% CD105+ cells, and at least about 95% CD166+ cells. Optionally, MSCs of the present preparations are isogenic and can be expanded ex vivo and cryo-preserved and thawed, yet maintain a stable and uniform phenotype. Methods are taught here of expanding these MSCs to produce a clinical scale therapeutic preparations and medical uses thereof.</p>
申请公布号
WO2012048093(A3)
申请公布日期
2012.08.02
申请号
WO2011US55072
申请日期
2011.10.06
申请人
OSIRIS THERAPEUTICS, INC.;TOM, SAMSON;TON, CHRISTOPHER;DANILKOVITCH, ALLA