USE OF (S) - ESMOLOL FOR CONTROLLING VENOUS IRRITATION ASSOCIATED WITH THE TREATMENT OF A CARDIAC DISORDER
摘要
<p>A pharmaceutical composition comprising (S)-methyl-3-[4-(2-hydroxy-3- isopropylamino) propoxy] phenylpropionate in a concentration between about 75 mM and about 150 mM, which is substantially free of the R-isomer or pharmaceutically acceptable salt thereof, is provided. A method of treating a cardiac disorder is also provided and includes administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising (S)-methyl-3-[4-(2-hydroxy-3-isopropylamino) propoxy] phenylpropionate hydrochloride, wherein the (S)-methyl-3-[4-(2-hydroxy-3-isopropylamino) propoxy] phenylpropionate hydrochloride is present at a concentration between about 75 mM and about 150 mM and wherein the pharmaceutical composition is substantially free of (R)-methyl-3-[4-(2-hydroxy-3-isopropylamino) propoxy] phenylpropionate or pharmaceutically acceptable salt thereof.</p>
申请公布号
WO2012103305(A1)
申请公布日期
2012.08.02
申请号
WO2012US22679
申请日期
2012.01.26
申请人
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;GASS, JEROME, H.;MCKEE, JEFF;RABINOW, BARRETT