METHOD FOR PRODUCING DI(ARYLAMINO)ARYL COMPOUND, AND SYNTHETIC INTERMEDIATE THEREFOR

摘要

Provided is a method for producing a di(arylamino)aryl compound which has superior inhibitory activity against kinase activity of EML4-ALK fusion protein and mutant EGFR protein and which is useful as an active ingredient in a pharmaceutical composition for treating cancer, the method being low cost and high yield with greatly improved overall yield, and being suitable for the industrial production of a pharmaceutical product without comprising a purification step involving the use of silica gel column chromatography, nor a step in which a mutagenic mesylate ester can occur as a byproduct. Also provided is a synthetic intermediate that is useful in the method for producing the di(arylamino)aryl compound.