摘要 |
The present invention provides compounds of Formula (I), wherein: R1a and R1b are independently hydrogen or methyl; or R1a and R1b are taken together to form a cyclopropyl ring; R2 is methyl or fluoromethyl; R3 is methyl; R4 is hydrogen, halo, fluoromethyl, methoxy, or fluoromethoxy; R5 is hydrogen, halo, fluoromethyl, methoxy, or fluoromethoxy; R6 is hydrogen, halo, methyl, or methoxy; R7 is hydrogen, halo, methyl, or methoxy; X is CH(R8); and R8 is hydrogen or C1-C6 alkyl or cycloalkyl; or pharmaceutically acceptable salts thereof. Compositions and methods of use thereof are also described. |
申请人 |
EISAI R&D MANAGEMENT CO., LTD.;BERTINATO, PETER;SATOH, TAKASHI;SPYVEE, MARK |
发明人 |
BERTINATO, PETER;SATOH, TAKASHI;SPYVEE, MARK |