发明名称 |
NOVEL ANTI-MICROBIAL PEPTIDOMIMETIC COMPOUNDS AND METHODS TO CALCULATE ANTI-MICROBIAL ACTIVITY |
摘要 |
This invention encompasses synthetic antimicrobial peptide analogs having certain un-natural amino acids, including the un-natural amino acids hydrophobic tetrahydroisoquinolinecarboxylic acid (Tic) and octahydroindolecarboxylic acid (Oic), incorporated into the polypeptide backbone. These antimicrobial peptides (AMPs) are useful to treat infection in humans and other mammals of such bacteria as Gram positive bacteria, Gram negative bacteria and Mycobacterium. Many of the AMPs also exhibit the property of reduced hemolytic activity. The invention also entails 3D-QSAR models and mathematical equations that calculate the biological activity of any peptide sequence against Staphylococcus aureus or Mycobacterium ranae. |
申请公布号 |
US2012197004(A1) |
申请公布日期 |
2012.08.02 |
申请号 |
US201213424827 |
申请日期 |
2012.03.20 |
申请人 |
HICKS RICKEY P.;VENUGOPAL DIVA KARAMENON;BHONSLE JAYENDRA |
发明人 |
HICKS RICKEY P.;VENUGOPAL DIVA KARAMENON;BHONSLE JAYENDRA |
分类号 |
C07K2/00 |
主分类号 |
C07K2/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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