发明名称 |
ANIONIC POLYMER, POLYION COMPLEX AND TERNARY POLYMER COMPOSITE USING ANIONIC POLYMER, AND PHARMACEUTICAL COMPOSITION |
摘要 |
There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: -A-B—X where : A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer. |
申请公布号 |
US2012196810(A1) |
申请公布日期 |
2012.08.02 |
申请号 |
US201013386554 |
申请日期 |
2010.07.23 |
申请人 |
KATAOKA KAZUNORI;ISHII ATSUSHI;TAKEMOTO HIROYASU;NAKANISHI MASATAKA;NISHIYAMA NOBUHIRO;MIYATA KANJIRO;THE UNIVERSITY OF TOKYO |
发明人 |
KATAOKA KAZUNORI;ISHII ATSUSHI;TAKEMOTO HIROYASU;NAKANISHI MASATAKA;NISHIYAMA NOBUHIRO;MIYATA KANJIRO |
分类号 |
A61K38/14;C07K2/00 |
主分类号 |
A61K38/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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