siRNA for inhibiting c-Met expression and an anti-cancer composition comprising the same

摘要

The present invention provides a small interfering ribonucleic acid (siRNA) which is complementarily bonded to a base sequence of c-Met transcript (mRNA transcript) to suppress c-Met expression in a cell as well as optionally to not induce immunological reactions, and applications of the siRNA for cancer prevention and/or treatment. The siRNA, which is bonded complementarily to the mRNA involved in the encryption of the c-Met, suppresses c-Met expression which is overexpressed in nearly all cancer cells in common due to the RNA interference (RNAi) phenomenon and inhibits the proliferation and metastasis of the cancer cells, thereby making the siRNA very useful as an anticancer agent.