OPTICAL ANALYTE DETECTION SYSTEMS AND METHODS OF USE

摘要

Disclosed are systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of binding to the analyte to form a duplex or complex, and an antibody capable of binding to the analyte, duplex, or complex. Also disclosed are systems and methods further include a particle attached to the antibody or capable of binding to the antibody. Also disclosed are systems and methods for analyte detection feature one or more of the following: high detection sensitivity and specificity, scalability and multiplex capacity, ability to analyze large analytes, and ability to detect or measure multiple individual binding events in realtime.