METHOD AND APPARATUS FOR DISCOVERY, DEVELOPMENT AND CLINICAL APPLICATION OF MULTIPLEX ASSAYS BASED ON PATTERNS OF CELLULAR RESPONSE

摘要

A method for deriving a multiplex cell response assay (MCRA), the method comprising: obtaining at least one specimen that has been phenotyped and classified with respect to the disease of interest using existing diagnostic techniques; adding of at least one stimulatory or inhibitory agent; isolating or separating at least one cell type; performing a multiplex measurement of cellular responses in each of the at least one cell type; and computationally deriving a clinically useful biomarker algorithm.