发明名称 |
RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY |
摘要 |
Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti cancer compounds are also described herein. |
申请公布号 |
US2012197060(A1) |
申请公布日期 |
2012.08.02 |
申请号 |
US201013378731 |
申请日期 |
2010.06.17 |
申请人 |
RAY ABHIJIT;GHANDEHARI HAMIDREZA;UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
RAY ABHIJIT;GHANDEHARI HAMIDREZA |
分类号 |
A61M37/00;A61P35/00;C07F15/00;C07H23/00;C08F222/38 |
主分类号 |
A61M37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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