发明名称 |
INDUCED PRESOMITIC MESODERM (IPSM) CELLS AND THEIR USE |
摘要 |
The invention relates to a method for reprogramming target cells to multipotent progenitor cells capable of differentiating into muscular, skeletal or dermal cell lines. In particular, the invention relates to an ex vivo method for preparing induced presomitic mesoderm (iPSM) cells, said method comprising the steps of: a) providing target cells to be reprogrammed, and, b) culturing said target cells under appropriate conditions for reprogramming said target cells into iPSM cells, wherein said appropriate conditions comprises increasing expression of at least one T-Box transcription factor in said target cells. The invention further relates to the use of said iPSM cells, for example, for regenerating skeletal, muscle, dermal and cartilage tissues. |
申请公布号 |
WO2012101114(A1) |
申请公布日期 |
2012.08.02 |
申请号 |
WO2012EP51029 |
申请日期 |
2012.01.24 |
申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE DE STRASBOURG;ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS;STOWERS INSTITUTE FOR MEDICAL RESEARCH;POURQUIE, OLIVIER;WAHL, MATTHIAS;CHAL, JEROME |
发明人 |
POURQUIE, OLIVIER;WAHL, MATTHIAS;CHAL, JEROME |
分类号 |
C12N5/074 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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地址 |
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