发明名称 |
Combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo- phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide and the Akt inhibitor N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1- methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide |
摘要 |
<p>The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.</p> |
申请公布号 |
EP2480085(A1) |
申请公布日期 |
2012.08.01 |
申请号 |
EP20100819438 |
申请日期 |
2010.09.23 |
申请人 |
GLAXOSMITHKLINE LLC |
发明人 |
DUMBLE, MELISSA;GILMER, TONA;KUMAR, RAKESH;LEBOWITZ, PETER, F.;MORRIS, SHANNON, RENAE;LAQUERRE, SYLVIE |
分类号 |
A01N43/54;A61K31/415;A61K31/505 |
主分类号 |
A01N43/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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