摘要 |
<p>The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.</p> |
申请人 |
BRIGHAM & WOMEN'S HOSPITAL;BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
KUCHROO, VIJAY, K.;STROM, TERRY;CHA, EUGENE, K.;CHAKRAVARTI, SUMONE;SABATOS, CATHERINE;ZHU, CHEN;ZHENG, XIN, XIAO;SANCHEZ-FUEGO, ALBERTO |