发明名称 |
Compounds for delivery of therapeutic and imaging moieties to nerve cells |
摘要 |
The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.
|
申请公布号 |
US8232251(B2) |
申请公布日期 |
2012.07.31 |
申请号 |
US20080323421 |
申请日期 |
2008.11.25 |
申请人 |
HILL G. CRAIG;KAHL STEPHEN B.;WEBB ROBERT R.;MCKEE CONSTANCE A.;MANZANITA PHARMACEUTICALS, INC. |
发明人 |
HILL G. CRAIG;KAHL STEPHEN B.;WEBB ROBERT R.;MCKEE CONSTANCE A. |
分类号 |
A61K38/16;A61K47/28;A61K47/48 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|