发明名称 |
Peptide antibody depletion and its application to mass spectrometry sample preparation |
摘要 |
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant and/or well-ionizing and/or proteotypic peptides from the sample. Also described are methods for identifying well-ionizing peptides for use in this and other methods; analytic (diagnostic) methods using antibodies against highly ionizable peptides from a protein target of interest; and compositions kits and devices comprising antibodies of the invention. |
申请公布号 |
US8232066(B2) |
申请公布日期 |
2012.07.31 |
申请号 |
US20070307510 |
申请日期 |
2007.07.03 |
申请人 |
VAN EYK JENNIFER E.;GRAHAM DAVID RAYMOND;GUNDRY REBEKAH LYNN;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
VAN EYK JENNIFER E.;GRAHAM DAVID RAYMOND;GUNDRY REBEKAH LYNN |
分类号 |
G01N31/00;G01N33/53 |
主分类号 |
G01N31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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