发明名称 |
p49/STRAP is a novel protein involved in gene regulation and cell proliferation |
摘要 |
The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP. |
申请公布号 |
US8232098(B2) |
申请公布日期 |
2012.07.31 |
申请号 |
US20080283347 |
申请日期 |
2008.09.11 |
申请人 |
WEI JEANNE Y.;ZHANG XIAOMIN;THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
WEI JEANNE Y.;ZHANG XIAOMIN |
分类号 |
C12N15/00;C07H21/02 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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