发明名称 |
Tumorspecifikke genkendelsesmolekyler |
摘要 |
<p>Recognition molecules (RM), especially antibodies (A) that bind specifically to the Core-1 (C1) antigen, comprising defined amino acids sequences (1-6) given in the specification and below, are new. Recognition molecules (RM), especially antibodies (A) that bind specifically to the Core-1 (C1) antigen, comprising defined amino acids sequences (1-6): (a) AsnTyrTrpLeuGly (1); (b) AspIleTyrPro(Gly) 3TyrThrAsnTyrAsnGluLysPheLysGly (2); (c) AspIleTyrPro(Gly) 2SerTyrThrAsnTyrAsnGluLysPheLysGly (3); (d) TyrAspAlaAlaGlyProTrpPheAlaTyr (4); (e) TyrAspAlaAlaGlyProGlyPheAlaTyr (5); or (f) TyrAspAsnHisTyrPheAspTyr (6). Independent claims are also included for: (1) construct (B) consisting of (A) fused, chemically coupled or non-covalently associated with additional sequences and/or structures; (2) isolated nucleic acid (NA) containing sequences that encode at least one (A) or (B); (3) expression cassette or vector (X) comprising NA and functionally linked promoter; (4) virus or host cell that contains at least one (X); (5) organism that contains at least one host cell of (4); (6) method for preparing (A); and (7) kit containing (A) and/or (B). ACTIVITY : Cytostatic. A multibody (104; sequence of about 200 amino acids reproduced) was coupled to a chelating group then loaded with yttrium99. It was injected (dose 100 MicroCi) into the tail vein of a mouse, subcutaneously implanted with ZA-75-1 (Core-1 positive) tumor cells. A second dose was given after 3 weeks and this treatment produced a significant reduction in tumor growth (no figures given). MECHANISM OF ACTION : Neutralization of Core-1 antigen; Vaccine.</p> |
申请公布号 |
DK1975183(T3) |
申请公布日期 |
2012.07.30 |
申请号 |
DK20080158547T |
申请日期 |
2003.12.01 |
申请人 |
GLYCOTOPE GMBH |
发明人 |
GOLETZ, STEFFEN;DANIELCZYK, ANTJE;STAHN, RENATE;KARSTEN, UWE;RAVN, PETER;CHRISTENSEN, PETER, ASTRUP |
分类号 |
C07K16/30;A61K39/00;A61K47/48;A61K51/10;C12N5/00 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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