| 摘要 |
A compound represented by the following general formula (I):which is converted into retinoid after being absorbed in vivo, or its salt or ester, wherein Rto Rrepresent each a hydrogen atom, an alkyl group or a trialkylsilyl group; X represents -NH-CO-, -CO-NH-, -N(COR)-CO-, -CO-N(COR)- (wherein Rand Rrepresent each a lower alkoxy group or a carboxy-substituted phenyl group), etc.; and Z represents -Y-CH(R)-COOH, -CHO, -CH=CH-COOH or -COOR(wherein Y represents a single bond, -CH, -CH(OH)-, -CO-, -CO-NH- or -CO-NH-CH-CO-NH-; Rrepresents a hydrogen atom, or a lower alkyl group; and Rrepresents a hydrogen atom, -CH(R)-COOH (wherein Rrepresents a hydrogen atom, a lower alkyl group or a hydroxyl group), -[CHCH-O]-CH-CH-OH, -CH-O-[CHCH-O]-CH-OH or -[CH(CH)-CO-O]-CH(CH)-COOH (wherein n, m and p represent each an integer of 1 to 100)). |
